Executive Order 14355: Unlocking Cures for Pediatric Cancer With Artificial Intelligence

Childhood cancer remains the leading cause of disease-related death among U.S. children, and its incidence has risen significantly over the past five decades. This executive order directs federal agencies to harness artificial intelligence to accelerate diagnostics, research, and treatment breakthroughs using the data infrastructure built through the Childhood Cancer Data Initiative. It outlines priorities such as improving clinical trial design, integrating multimodal health data, enhancing predictive modeling, and advancing secure data-sharing standards. The order underscores the need for federal investment, private-sector engagement, and patient-centered data governance to drive meaningful progress.